DAVID DE GEA has not been included in Manchester United’s squad to face Southampton.
The shock move from Jose Mourinho will increase speculation that the Spanish keeper will join Real Madrid in summer.
Argentine understudy Sergio Romero starts, and has also been promised a starting berth against Ajax in the crucial Europa League final.
Meanwhile Zlatan Ibrahimovic, James Wilson and Marcos Rojo are long-term absentees, with Timothy Fosu-Mensah and Ashley Young also out.
Luke Shaw is also set to miss the Premier League clash with a foot injury.
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Southampton on the other hand are set to be missing just two players for their game against United.
Virgil van Dijk misses another game with his foot injury.
And Alex McCarthy is also due to be unavailable with a hamstring strain.
Here's everything else you need to know about the clash...
Where can I watch Southampton vs Manchester United?
United travel to the south coast to take on Southampton on Wednesday May 17, with kick-off at 7.45pm.
The match will be shown live on Sky Sports 1, with Sky Go subscribers able to stream to game live on the app.
Alternatively, you can follow all the action on our live blog and watch the goals as they go in on our app.
Premier League form guide
SOUTHAMPTON - WLDDL
MAN UNITED - LLDDW
Southampton may not have been in the best of form, but Man United have failed to win in their last four games.
Mourinho's side have lost their last two games against Arsenal and Tottenham to concede their fight for a top four spot this term.
Expect both teams to wind down their season with a less-than-intense draw. 1-1.